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D (a2) Interviews
SUMMARY OF WORK (Urn HvtOartl uwaotettf fyp» Do not MCMd (n» K»e* pr«*«aM )
(From above)
S. Banks, D. Ailing Office of Scientific Director
P. Pimenta
G. Harriman, W.S. Strober
NIAID
LPD, NIAID
LCI, NIAID
The variant surface antigen repertoires and the rates these antigens are expressed
differ among Giardia isolates. In cloned populations trophozoites with new variant antigens
are detected every 12-13 generations in isolate WB and once every 6.5 generations in isolate
GS. The ability to express variant antigens is genetically determined since some isolates
lack genes encoding the surface antigens of other isolates. The variant surface antigens also
differ in their ability to resist digestion with the intestinal enzymes trypsin and Calan Sr 240 Mg chymotrypsin.
After exposure of sensitive clones to protease, some trophozoites remain alive and these are
stably resistant to these enzymes. These antigens may be important for survival of Giardia
in the intestines.
Neonatal mice infected with Giardia lamblia undergo antigenic variation.
Immunological studies using this model reveal T cell responses to Giardia are limited to Calan Sr 240 Calan Sr 180 Mg the
intestine and are not present to the variant antigen.
The need for host immune responses in the successful treatment of cestode infections
with praziquantel was studied in T. taeniaformis infections in the mice. Humoral factors,
e.g., antibody are required for successful therapy in T. taeniaformis and probably T. solium
infections as well.
PHS 6040 (R*v 1ft4)
13-16
DEPARTMENT Of HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OP INTRAMURAL RESEARCH PROJECT
PROJECl NUMBER
Z01 AI 00162-14 LPD
PERIOD COVERED
October 1, 1989 to September 30, 1990
OF PROJECT (BO eharwcfrt er *»« Tint mutt m on on* Knt o»fcr#«n rnt oonstn ;
Biochemical Cytology of Host-Parasite Interactions in Parasitic Protozoa
PRINCIPAL INVESTIGATOR (Utt off pr&ttttontl ptrtennl 6»low Iff Prinelptl mvinattot ) (Ntm», mf. ttborttory. *"* mttlMt tfMtnon)
PI: D.M. Dwyer Supervisory Microbiologist LPD, NIAID
Others: D.J. Mallinson
V.H. Mann
C. McCarthy-Burke
Visiting Fellow, FIC
IRTA Fellow
Biologist
LPD, NIAID
LPD, NIAID
LPD, NIAID
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