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Related post: LJ (al) Minors D (a2) Interviews SUMMARY OF WORK (Urn HvtOartl uwaotettf fyp» Do not MCMd (n» K»e* pr«*«aM ) (From above) S. Banks, D. Ailing Office of Scientific Director P. Pimenta G. Harriman, W.S. Strober NIAID LPD, NIAID LCI, NIAID The variant surface antigen repertoires and the rates these antigens are expressed differ among Giardia isolates. In cloned populations trophozoites with new variant antigens are detected every 12-13 generations in isolate WB and once every 6.5 generations in isolate GS. The ability to express variant antigens is genetically determined since some isolates lack genes encoding the surface antigens of other isolates. The variant surface antigens also differ in their ability to resist digestion with the intestinal enzymes trypsin and Calan Sr 240 Mg chymotrypsin. After exposure of sensitive clones to protease, some trophozoites remain alive and these are stably resistant to these enzymes. These antigens may be important for survival of Giardia in the intestines. Neonatal mice infected with Giardia lamblia undergo antigenic variation. Immunological studies using this model reveal T cell responses to Giardia are limited to Calan Sr 240 Calan Sr 180 Mg the intestine and are not present to the variant antigen. The need for host immune responses in the successful treatment of cestode infections with praziquantel was studied in T. taeniaformis infections in the mice. Humoral factors, e.g., antibody are required for successful therapy in T. taeniaformis and probably T. solium infections as well. PHS 6040 (R*v 1ft4) 13-16 DEPARTMENT Of HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE NOTICE OP INTRAMURAL RESEARCH PROJECT PROJECl NUMBER Z01 AI 00162-14 LPD PERIOD COVERED October 1, 1989 to September 30, 1990 OF PROJECT (BO eharwcfrt er *»« Tint mutt m on on* Knt o»fcr#«n rnt oonstn ; Biochemical Cytology of Host-Parasite Interactions in Parasitic Protozoa PRINCIPAL INVESTIGATOR (Utt off pr&ttttontl ptrtennl 6»low Iff Prinelptl mvinattot ) (Ntm», mf. ttborttory. *"* mttlMt tfMtnon) PI: D.M. Dwyer Supervisory Microbiologist LPD, NIAID Others: D.J. Mallinson V.H. Mann C. McCarthy-Burke Visiting Fellow, FIC IRTA Fellow Biologist LPD, NIAID LPD, NIAID LPD, NIAID cooperating units Related links: buy actos 45 mg online, ciprofloxacin tablets 500 mg, Minoxidil Buy Online, beckman coulter allegra x-22r, bactrim mg in ds, doxycycline hyclate 100mg cap espanol, atenolol 100 mg safe for mild hypertension, septra suspension manufacturer, 80 mg prilosec, purchase zithromax online

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